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. 2019 Dec 13;87(1):30–39. doi: 10.1002/ana.25642

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© 2019 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Mendelian randomization estimates for the effects of exposure to drug target modulation on coronary artery disease (CAD) and type 2 diabetes mellitus (T2D). Results were produced using variants within gene regions (±1 kilobase flanks) and the principal components–based method, as per analyses for the Alzheimer disease results presented in Figure 1. Sample sizes: CAD, n = 22,233 cases, 64,762 controls; T2D, n = 12,171 cases, 56,862 controls. CI = confidence interval; LDL‐C = low‐density lipoprotein cholesterol; OR = odds ratio; SD = standard deviation; SNP = single nucleotide polymorphism.