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. 2019 Nov;7(22):646. doi: 10.21037/atm.2019.10.54

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2019 Annals of Translational Medicine. All rights reserved.

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Immunosuppressive immune cells and T cell exhaustion markers enriched in patients with high level of arm copy number alterations. (A) Different features of immune cell composition in arm SCNA^high and arm SCNA^low tumors; (B) Treg cells metagene values in arm SCNA^high and arm SCNA^low tumors; (C) Macrophages metagene values in arm SCNA^high and arm SCNA^low tumors; (D) NK cells metagene values in arm SCNA^high and arm SCNA^low tumors; (E) PD-1 mRNA level in arm SCNA^high and arm SCNA^low tumors; (F) CTLA-4 mRNA level in arm SCNA^high and arm SCNA^low tumors; (G) LAG-3 mRNA level in arm SCNA^high and arm SCNA^low tumors; (H) TIGIT mRNA level in arm SCNA^high and arm SCNA^low tumors; (I) gene set enrichment analysis of “NEGATIE_REGULATION OF LYMPHOCYTE_MEDIATED_IMMUNITY” pathway in arm SCNA^high versus arm SCNA^low tumors. **, P<0.01. SCNA, somatic copy number alteration.