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. 2019 Nov;7(22):628. doi: 10.21037/atm.2019.11.02

Figure 4.

Figure 4

Gal-1 regulates DCs-induced Treg/Th17 balance through IL-27 pathway in CD4+ T cells (n=3). After treatment for 6 days in 4 conditions in the presence of GM-CSF (50 ng/mL), Th17 (IL17+CD4+) (A) and Treg (CD25+FoxP3+) (B) cell populations were qualified in CD4+ T cells by flow cytometry. (C) Treg/Th17 ratios were further calculated. Cytokines such as IL-17 (D), IL-10 (E), IL-27 (F) and TGF-β (G) were further measured by ELISA. Values indicate mean ± SEM of these experiments. *, P<0.05; **, P<0.01. DCs, dendritic cells; Gal, galectin; GM-CSF, granulocyte-macrophage colony-stimulating factor; Treg cell, regulatory T cell; ELISA, enzyme-linked immunosorbent assay.