Table 5. Hub genes identified in the PPI networks for the modules of interest.

Module	Gene Sybmol	Description	Degree	log2 FC	P value
Green	IL-6	Interleukin 6	36	2.54	1.62E–04
	CXCL8	C-X-C motif chemokine ligand 8	30	1.59	1.21E–03
	IL-1β	Interleukin 1 beta	27	1.36	5.00E–03
	MYC	MYC proto-oncogene, bhlh TF	25	1.07	5.10E–04
	PTGS-2	Prostaglandin-endoperoxide synthase 2	24	1.19	4.33E–04
Yellow	C3	Complement C3	14	–1.41	1.03E–05
	TIMP1	TIMP metallopeptidase inhibitor 1	9	–0.73	5.10E–04
	VSIG4	V-set and immunoglobulin domain containing 4	9	–0.66	7.42E–05
	SERPING1	Serpin family G member 1	9	–0.56	9.23E–06
	CD163	CD163 molecule	8	–0.68	3.57E–04
	HP	Haptoglobin	8	–2.91	2.15E–05

PPI, protein-protein interaction; FC, fold change.