Table 1. Clinical characteristics of patients grouped by 90-day mortality.
| Characteristics | All patients (N=77) | 90-day survival (n=61) | 90-day mortality (n=16) | P value |
|---|---|---|---|---|
| Gender (male), n (%) | 57 (74.0) | 44 (72.1) | 13 (81.2) | 0.54 |
| Age (years) | 52 [40–59] | 51 [38–59] | 55 [49.25–61.5] | 0.38 |
| Comorbidities | ||||
| Diabetes mellitus, n (%) | 9 (11.7) | 5 (8.2) | 4 (25.0) | 0.08 |
| Hypertension, n (%) | 57 (74.0) | 45 (73.8) | 12 (75.0) | 1.00 |
| Immunosuppression regimens before admission | ||||
| CsA + MMF + Pred, n (%) | 32 (41.6) | 25 (41.0) | 7 (43.8) | 1.00 |
| TAC + MMF + Pred, n (%) | 39 (50.6) | 31 (50.8) | 8 (50.0) | 1.00 |
| Rapa + MMF + Pred, n (%) | 6 (7.8) | 5 (8.2) | 1 (6.3) | 1.00 |
| Median time from transplantation to ICU admission, months | 8 [3–54] | 8 [3–54.5] | 5.5 [2.25–45.5] | 0.47 |
| Median time from fever onset to hospital admission, days | 6 [3–7] | 6 [3–7] | 5.5 [1.8–7.3] | 0.55 |
| Median time from fever onset to ICU admission, days | 7 [4–11] | 7 [4–11] | 8.5 [4–15.3] | 0.58 |
| Acute rejection history, n (%) | 13 (16.9) | 9 (14.75) | 4 (25.0) | 0.45 |
| APACHE II score at ICU admission | 12 [9–16] | 11 [9–14] | 17.5 [14–26] | <0.01 |
| PSI score at ICU admission | 114 [99–134] | 110 [98.5–128.5] | 131 [102.75–155] | 0.07 |
| CURB-65 score at ICU admission | 2 [2–3] | 2 [2–2] | 2.5 [2–3] | 0.05 |
| PaO2/FiO2 ratio (mmHg) at ICU admission | 197 [131–264] | 213 [150–274] | 127 [103–203] | <0.01 |
| LDH (U/L) | ||||
| LDHday 1 (U/L) | 360 [278–465] | 334 [265–432] | 440 [362–1,055] | <0.001 |
| LDHday 3 (U/L) | 334 [241–464.5] | 290 [223–387.5] | 522.5 [457.5–1,058.5] | <0.001 |
| LDHc (%) | −4.71 [−21.09–7.66] | −10.79 [−24.36–2.83] | 18.02 [6.59–42.14] | <0.001 |
| Outcome | ||||
| Median length of ICU stay, days | 7 [4–13] | 6 [3.5–10.5] | 16.5 [5.5–30] | 0.01 |
| Median length of hospital stay, days | 23 [14.5–31] | 21 [13–29] | 33 [20–46] | 0.04 |
| ICU mortality, n (%) | 14 (18.2) | 0 (0) | 14 (87.5) | <0.01 |
| Hospital mortality, n (%) | 16 (20.8) | 0 (0) | 16 (100.0) | <0.01 |
Values are median [interquartile range (IQR)] for continuous variables and percentages for categorical variables. The baseline immunosuppressive regimens included: CsA, cyclosporine A; TAC, tacrolimus; MMF, mycophenolate mofetil; Rapa, rapamycin; Pred, prednisone; APACHE-II, Acute Physiology and Chronic Health Evaluation II; PSI, Pneumonia Severity Index; ALT, alanine aminotransferase; LDHday1, LDH level at ICU admission; LDHday3, LDH level on day 3; LDHc, LDH change from day 1 to day 3 [calculated using the following formula: LDHc (%) = (LDHday3 – LDHday1)/LDHday1 ×100%].