Table 5. Multivariable cox regression analyses of CSS in all patients.

Variables	HR	95% CI lower	95% CI upper	P value
Gender (male vs. female)	0.885	0.690	1.135	0.337
Age	1.001	0.991	1.010	0.873
Tumor location
Lower	Ref	Ref	Ref	Ref
Middle	1.032	0.773	1.377	0.832
Upper	1.210	0.938	1.560	0.143
Tumor size (≥5 vs. <5 cm)	1.427	1.133	1.798	0.003
Differentiated (high vs. low)	1.571	1.228	2.010	<0.001
Chemotherapy	0.149	0.114	0.195	<0.001
pT stage
pT1	Ref	Ref	Ref	Ref
pT2	1.527	0.723	3.224	0.267
pT3	3.971	1.994	7.909	<0.001
pT4a	4.251	2.154	8.388	<0.001
pT4b	6.831	3.360	13.891	<0.001
pN stage
pN0	Ref	Ref	Ref	Ref
pN1	4.617	2.915	7.312	<0.001
pN2	5.765	3.733	8.904	<0.001
pN3a	9.735	6.296	15.053	<0.001
pN3b	8.861	5.570	14.096	<0.001
TD	1.905	1.470	2.469	<0.001

CSS, cancer-specific survival; HR, hazard ratio; CI, confidence interval; TD, tumor deposit.