Figure 5.

Anticancer effect of osimertinib plus DHA combination on FaDu and CAL27 xenografts in nude mice. Athymic nude female mice bearing FaDu (A) and CAL27 (B) xenografts were orally treated with 0.5% carboxymethyl cellulose sodium salt (vehicle), osimertinib 5 mg/kg, DHA 50 mg/kg, or osimertinib plus DHA. Tumor sizes were measured two or three times per week. Mean tumor volume and standard deviation are shown in A and B. Representative Photographs of mice in each group taken 30 days after treatment are shown in the upper panel of C (FaDu) and D (CAL27). The mean weight of tumors in nude mice at the time of sacrifice is presented in the lower panels of C (FaDu) and D (CAL27). Data shown are means with standard deviations of the tumor weight from five individual mice in each group. *P<0.05. All P values were calculated by one-way ANOVA. DHA, dihydroartemisinin.