Table I.

Parameter Estimates of the Final popPK Model

Parameter	Alias	Estimate	Relative SE (%)	95% CI	Shrinkage (%)
θ1	CL/F: Apparent systemic clearance (L∙h−1)	19.5	.....	(18.2–20.9)
θ2	V1/F: Apparent central volume of distribution (L)	381	.....	(333–437)
θ3	V2/F: Apparent peripheral volume of distribution (L)	284	.....	(254–318)
θ4	Q1/F: Apparent Intercompartmental clearance (L∙h−1)	52.8	.....	(44.1–63.2)
θ5	V3/F: Apparent second Peripheral volume of distribution (L)	273	.....	(222–336)
θ6	Q2/F: Apparent second intercompartmental clearance (L∙h−1)	4.47	.....	(3.73–5.36)
θ7	NTR: Number of transit compartments	14.9	.....	(13.0–17.1)
θ8	MTT: Mean transit time (h)	0.849	.....	(0.755–0.954)
θ9	Proportional residual error (%)	1.94	.....	(1.29–2.92)
θ11	Food effect on MTT	1.43	.....	(1.22–1.68)
θ12	PPI effect on MTT	0.835	.....	(0.692–1.01)
θ13	PPI and food effect on MTT	2.26	.....	(1.78–2.86)
θ14	PPI effect on F1	0.657	.....	(0.568–0.759)
θ15	PPI and food effect on F1	0.693	.....	(0.611–0.785)
θ16	Food effect on NTR	0.864	.....	(0.45–1.66)
θ17	Tablet effect on NTR	0.049	.....	(0.0287–0.0838)
θ18	Residual error rate in healthy volunteers	1.94	.....	(1.53–2.46)
θ19	Maximum residual error in healthy volunteers	6.66	.....	(4.21–10.6)
θ20	PPI effect on CL/F	0.663	.....	(0.650–0.675)
θ21	Proportional residual error in patients	0.390	.....	(0.372–0.408)
θ22	Age effect on CL/F	−0.161	41.4	(−0.291 - -0.0304)
θ23	Healthy volunteer effect on CL/F	1.52	.....	(1.27–1.82)
ω1.1	ω2CL/F	0.0732	14.9	(0.0518–0.0946)	27.3
ω2.2	ω2V1/F	0.100	22.6	(0.0558–0.145)	54.4
ω8.8	ω2MTT	0.0861	29.7	(0.0360–0.136)	58.1
ω9.9	ω2F1	0.131	17.1	(0.0872–0.175)	31.9
ω10.1	ω2IOV on F1	0.299	5.30	(0.268–0.330)	26.0

Log-transformed parameters have been back-transformed and thus relative SE (%) is not represented, instead 95% CI is appropriate

popPK population pharmacokinetics, SE standard error, CI confidence interval, PPI proton pump inhibitor, F1 absorption