Table 2.

Changes in nociceptive thresholds in 6-OHDA lesioned rats.

Rat Breed	Lesion location	Lesion type	Time when tests performed (weeks post-lesion)		Nociceptive	tests		Hind paw displaying change	Ref
				Heat	Mechanical	Chemical	Cold
Wistar	Left MFB	Unilateral	1, 4 & 12	n/a	↓	n/a	n/a	Both	90
	Left MFB	Unilateral	3	n/a	n/a	↓	n/a	Ipsilateral	91
	Right MFB	Unilateral	2 & 4	↓	n/a	n/a	n/a	n/d tail immersion	92
	left SNc	Unilateral	2	↓	↓	↓	↓	Both	75
	Right STR	Unilateral	4	↓	↓	↓	n/a	Contralateral	93
	Left STR	Unilateral	1, 2 & 3	↓	↓	n/a	n/a	Both	73
Sprague-Dawley	Right MFB	Unilateral	2	↓	↓	n/a	n/a	Both	73
	Right MFB	Unilateral	3	↓	↓	n/a	n/a	Contralateral	76
	MFB	Bilateral	2	n/a	↓	↓	n/a	Both	74
	MFB	Bilateral	2	n/a	↓	n/a	n/a	Both	94
	SNc	Bilateral	1, 2, 3 & 4	↓	↓	n/a	n/a	Both	77
	Right STR	Unilateral	5 & 6	↑	n/a	↓	n/a	Contralateral	95
	Left STR	Unilateral	1, 2 & 3	↓	↓	↓	n/a	Both	96

Table 2 summarises the outcome of all nociceptive studies performed in 6-OHDA lesioned rats. ↓ = a reduction in thresholds, ↑ = an increase in thresholds, n/a = test not performed, n/d = readout not determinable. MFB medial forebrain bundle, SNc Substantia nigra pars compacta, STR striatum