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. 2020 Jan 6;11(1):19. doi: 10.1038/s41419-019-2200-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Reactome over-representation tests: pathways highlighted in three main evolutions during TMZ treatment of U251^S. Gene ratio: proportion of mapped genes to each pathway. Count: number of genes. b Principal component analysis (PCA) (left), heatmap resulting from the transcriptome analysis of U251 after 0, 4, 9, 12, 16 days treatment with 50 µM TMZ (right). c Number of reads during acquisition of resistance for genes belonging to the apoptotic, EMT, and stemness families. d Functional protein association networks (STRING analysis) of genes over-expressed during the transient state (fold change > log2).