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. 2020 Jan 6;11(1):19. doi: 10.1038/s41419-019-2200-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Relative expression of the four selected markers at D9 in the RNAseq study. b Time course of KLK5, FAT2, CHI3L1 and HB-EGF by RT-qPCR in U251 cells treated with 50 µM TMZ every 3 days. Dotted line: fold change = 2. c TCGA glioblastoma database analysis for KLK5, FAT2, CHI3L1, and HB-EGF expression (RNAseq profile with a score threshold +/−2): Kaplan–Meier estimate of overall survival (left), and disease/progression-free (right). d Cell viability of U251 cells treated with siRNA directed against the respective genes and treated or not with TMZ 50 µM as detailed in Methods. Cells were collected and counted on day 7.