Mean 3-year cognitive trajectories by baseline NRI in the multidomain Alzheimer prevention trial (n = 712). NRI increases by one point for the following: omega-3 polyunsaturated fatty acid(EPA+DHA) ≤4.82 wt%; serum 25-hydroxyvitamin D ≤20 ng/mL; plasma homocysteine ≥14 μmol/L. (A) Mean 3-year cognitive composite Z score trajectories by baseline NRI 0, 1, 2, and 3. (B) Mean 3-year cognitive composite Z score trajectories by each distinct NRI-1 profile with NRI-0 and NRI-3 included for comparison. (C) Mean 3-year cognitive composite Z score trajectories by each distinct NRI-2 profile with NRI-0 and NRI-3 included for comparison. Abbreviations: NRI, nutritional risk index; SU, standard units; HCy, homocysteine.