Table 3.
Mean differences in cognitive trajectories according to the NRI scores in the MAPT (n = 712)
| characteristic | ß coefficient estimate | SE | Pr > |t| |
|---|---|---|---|
| Intercept | 2.4787 | 0.4296 | <0.0001 |
| Age, y | −0.0329 | 0.0055 | <0.0001 |
| Time, y | 0.0168 | 0.0211 | 0.4256 |
| Gender, men compared with women | −0.1869 | 0.0532 | 0.0005 |
| Education | |||
| No diploma/primary school | 0 | — | — |
| Secondary education | 0.1004 | 0.0665 | 0.1317 |
| High-school diploma | 0.4657 | 0.0828 | <0.0001 |
| College or more | 0.4671 | 0.0706 | <0.0001 |
| NRI, baseline | |||
| 0 (reference group) | 0 | — | — |
| 1 | −0.1408 | 0.0686 | 0.0403 |
| 2 | −0.1010 | 0.0722 | 0.1621 |
| 3 | −0.3864 | 0.1004 | 0.0001 |
| NRI × time (y) | |||
| 0 (reference group) | 0 | — | — |
| 1 | −0.0451 | 0.0211 | 0.0331 |
| 2 | −0.0875 | 0.0219 | <0.0001 |
| 3 | −0.1101 | 0.0327 | 0.0008 |
NOTE. Model adjusted for baseline age, gender, education, trial arm, and trial arm × time interaction; primary outcome measure is the cognitive composite Z score. NRI increases by one point for each of the following: omega-3 PUFA (O3) ≤4.82 wt%; serum 25-OH D ≤20 ng/mL; and plasma homocysteine ≥14 μmol/L.
Abbreviations: NRI, nutritional risk index; MAPT, multidomain Alzheimer prevention trial; SE, standard error.