Table 3.
Hypoglycemic group | Baseline | 3 months | 6 months | 9 months | 12 months |
---|---|---|---|---|---|
n (%) | |||||
Total | 5,770 | 4,989 | 4,817 | 4,658 | 4,562 |
No OHA or insulin | |||||
Total | 2,575 (44.6) | 1,051 (21.1) | 1,035 (21.5) | 1,022 (21.9) | 1,089 (23.9) |
Diet and exercises | 2,527 (43.8) | 995 (19.9) | 982 (20.4) | 977 (21.0) | 1,040 (22.8) |
Herbal medicine | 48 (0.8) | 56 (1.1) | 53 (1.1) | 45 (1.0) | 49 (1.1) |
One OHA, no insulin | |||||
Total | 1,308 (22.7) | 1,657 (33.2) | 1,636 (34.0) | 1,585 (34.0) | 1,532 (33.6) |
MF | 713 (12.4) | 893 (17.9) | 901 (18.7) | 865 (18.6) | 836 (18.3) |
AGI | 236 (4.1) | 299 (6.0) | 287 (6.0) | 277 (5.9) | 284 (6.2) |
SU | 220 (3.8) | 251 (5.0) | 258 (5.4) | 261 (5.6) | 242 (5.3) |
Others† | 139 (2.4) | 214 (4.3) | 190 (3.9) | 182 (3.9) | 170 (3.7) |
Two OHAs, no insulin | |||||
Total | 742 (12.9) | 955 (19.1) | 941 (19.5) | 934 (20.1) | 902 (19.8) |
MF + SU | 268 (4.6) | 343 (6.9) | 361 (7.5) | 368 (7.9) | 341 (7.5) |
MF + AGI | 138 (2.4) | 174 (3.5) | 178 (3.7) | 165 (3.5) | 166 (3.6) |
AGI + SU | 99 (1.7) | 125 (2.5) | 121 (2.5) | 128 (2.7) | 126 (2.8) |
MF + glinides | 93 (1.6) | 109 (2.2) | 92 (1.9) | 85 (1.8) | 95 (2.1) |
MF + others | 77 (1.3) | 112 (2.2) | 109 (2.3) | 112 (2.4) | 101 (2.2) |
Any combinations except listed above | 67 (1.2) | 92 (1.8) | 80 (1.7) | 76 (1.6) | 73 (1.6) |
More than two OHAs, no insulin | |||||
Total | 122 (2.1) | 181 (3.6) | 191 (3.8) | 165 (3.5) | 140 (3.1) |
Insulin only, no OHA | |||||
Total | 559 (9.7) | 557 (11.2) | 481 (9.6) | 480 (10.3) | 463 (10.1) |
Insulin + one OHA | |||||
Total | 318 (5.5) | 384 (7.7) | 353 (7.1) | 315 (6.8) | 305 (6.7) |
MF | 167 (2.9) | 189 (3.8) | 174 (3.5) | 151 (3.2) | 139 (3.0) |
AGI | 97 (1.7) | 120 (2.4) | 111 (2.2) | 107 (2.3) | 106 (2.3) |
Others | 54 (0.9) | 75 (1.5) | 68 (1.4) | 57 (1.2) | 60 (1.3) |
Insulin + two OHAs | |||||
Total | 122 (2.1) | 167 (3.3) | 155 (3.2) | 133 (2.9) | 111 (2.4) |
Insulin + more than two OHAs | |||||
Total | 24 (0.4) | 37 (0.7) | 25 (0.5) | 24 (0.5) | 20 (0.4) |
†Dipeptidyl peptidase‐4 inhibitors were included in others. AGI, α‐glucosidase inhibitor; MF, metformin; OHA, oral hypoglycemic agent; SU, sulfonylureas.