Table 1.
The most frequently known EV‐associated proteins are detected in the schistosomal‐EV proteomic analysis
| Mammalian gene symbol | Number of times a protein was identified in other EV studies according to Vesiclepedia 51 | Protein name | Schistosome unique accession number protein from FASTA database | Total number of reads of the identified peptides mapped to the specific protein | The cover of the aligned protein, in percentage by the identified peptides. | Percentage of identity between human and the schistosomal protein | |
|---|---|---|---|---|---|---|---|
| 1 | PDCD6IP | 399 | Programmed cell death 6‐interacting protein | 353233402: putative programmed cell death protein | 3 | 13.22 | 45% |
| 2 | GAPDH | 377 | Glyceraldehyde‐3‐phosphate dehydrogenase | 353229455;353229454;353229456;353229457; glyceraldehyde‐3‐phosphate dehydrogenase | 15 | 51.35 | 73% |
| 3 | HSPA8 | 363 | Heat shock 70 kDa protein 8 | 552242;10168;353229993;353230065;Q27965;Q0VCX2;P0CB32;P19120;Q27975;P34933: putative heat shock protein 70 | 32 | 34.54 | 83% |
| 4 | ACTB | 350 | Beta actin | 678545;924603;353233031;353233035;353233111;360045418;360045419;P62739;P60712;Q3ZC07;P63258;Q5E9B5;P68138;F1MRD0;G8JKX4;F1MKC4; actin | 39 | 46.06 | 97% |
| 5 | ANXA2 | 337 | Annexin A2 | 353232899: putative annexin | 3 | 9.22 | 33% |
| 6 | CD9 | 328 | SM23 molecule | 161030;11890;350646174: integral membrane protein 23 | 6 | 25.23 | 27% |
| 7 | PKM | 327 | Pyruvate kinase | 353230308;353230309 putative pyruvate kinase [Schistosoma mansoni] | 37 | 56.74 | 62% |
| 8 | ENO1 | 327 | Enolase 1, (alpha) | 1002610;360044945;Q3ZC09;A6QR19; enolase | 14 | 23.27 | 75% |
| 9 | HSP90AA1 | 327 | Heat shock protein 90 kDa alpha | 7673568;353230104;353230105;360043333;360043335;Q95M18;Q76LV1;G3N2V5;G5E507; putative heat shock protein | 27 | 30.97 | 66% |
| 10 | CD63 | 306 | CD63 molecule | 353233656;575403085;23305772;353232346;353231401; putative tetraspanin‐CD63 receptor | 45 | 29.29 | 21% |
| 11 | EEF1A1 | 295 | Translation elongation factor 1‐alpha | 353230261;P68103;Q32PH8;G3N2F0;E1BPF4;E1B7J1;E1B9F6;E1BED8 putative elongation factor 1‐alpha (ef‐1‐alpha) | 6 | 11.83 | 78% |
| 12 | PGK1 | 291 | Phosphoglycerate kinase | 556413;360043465 phosphoglycerate kinase [Schistosoma mansoni] | 2 | 13.37 | 69% |
| 13 | ALDOA | 275 | Fructose‐bisphosphate aldolase | 605647;353232336 fructose 1,6 bisphosphate aldolase [Schistosoma mansoni] | 36 | 66.94 | 67% |