Table 3.
Univariate and multivariate analyses in 165 patients with resected pancreatic head carcinoma
| Variable | Patients | Survival, % |
p (Log-rank test) | Multivariate |
|||||
|---|---|---|---|---|---|---|---|---|---|
| 1-year | 2-year | hazard ratio (95% CI) | p value | ||||||
| LMR | 0.015 | 0.042 | |||||||
| <2.8 | 25 | 36.1 | 18.6 | 1.72 (1.02 | −2.89) | ||||
| ≥2.8 | 140 | 66.2 | 40.5 | 1.00 | |||||
| CEA, ng/dL | 0.120 | ||||||||
| ≤5.0 | 121 | 58.6 | 34.3 | ||||||
| >5.0 | 40 | 71.1 | 43.3 | ||||||
| CA19-9, U/mL | 0.057 | ||||||||
| <37 | 40 | 74.7 | 46.1 | ||||||
| ≥37 | 120 | 56.7 | 32.7 | ||||||
| PV resection | <0.001 | ||||||||
| None | 61 | 80.4 | 56.7 | ||||||
| Resected | 104 | 51.3 | 26.0 | ||||||
| Size, cm | 0.069 | ||||||||
| ≤2.0 | 19 | 94.4 | 63.8 | ||||||
| >2.0 | 146 | 57.6 | 33.9 | ||||||
| Lymphatic invasion | 0.001 | 0.030 | |||||||
| Absent | 14 | 92.3 | 92.3 | 1.00 | |||||
| Present | 151 | 59.1 | 31.9 | 2.81 (1.17–7.12) | |||||
| Venous invasion | <0.001 | 0.006 | |||||||
| Absent | 69 | 76.1 | 54.6 | 1.00 | |||||
| Present | 96 | 51.0 | 23.3 | 1.87 (1.19 | −2.93) | ||||
| Perineural invasion | 0.001 | ||||||||
| Absent | 14 | 100.0 | 90.0 | ||||||
| Present | 151 | 58.4 | 32.9 | ||||||
| Anterior serosal infiltration | 0.003 | ||||||||
| Absent | 85 | 70.7 | 45.1 | ||||||
| Present | 80 | 52.0 | 28.3 | ||||||
| Retroperitoneal invasion | <0.001 | ||||||||
| Absent | 52 | 78.4 | 61.3 | ||||||
| Present | 113 | 54.6 | 26.5 | ||||||
| Bile duct invasion | 0.135 | ||||||||
| Absent | 60 | 68.6 | 44.7 | ||||||
| Present | 105 | 58.2 | 33.2 | ||||||
| Duodenal invasion | 0.428 | ||||||||
| Absent | 80 | 63.5 | 42.6 | ||||||
| Present | 85 | 60.4 | 32.2 | ||||||
| Plexus invasion | <0.001 | ||||||||
| Absent | 104 | 70.4 | 47.5 | ||||||
| Present | 61 | 48.4 | 20.5 | ||||||
| PV/SMV invasion | <0.001 | ||||||||
| Absent | 106 | 72.2 | 45.6 | ||||||
| Present | 59 | 44.3 | 23.2 | ||||||
| Lymph node metastasis | 0.002 | ||||||||
| Absent | 54 | 72.5 | 53.9 | ||||||
| Present | 111 | 56.8 | 29.4 | ||||||
| Surgical margin | <0.001 | <0.001 | |||||||
| Negative | 130 | 73.5 | 45.5 | 1.00 | |||||
| Positive | 35 | 19.5 | 7.8 | 2.88 (1.81–4.59) | |||||
Expressed as n (%) or median (range).
LMR, lymphocyte-to-monocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index; PV, portal vein; SMV, superior mesenteric vein.