Table 1.

The results of the ten TCRαβ and CD19 depletion procedures

Patient No.		Weight, kg		Start material					Log depletion		Target cells				% product administered		TCRαβ 103/kg administered
TNC 109	CD34 106	CD34 106/kg	TCRαβ, % of TNC	CD20, % of TNC	TCRαβ	CD20	CD34 106/kg	CD34, % recovery	TCRαβ 103/kg	CD20 103/kg
1	17.3	61	1,029	59.5	15.1	0.9	−4.15	−3.12	58.7	99	37.0	22.8	33	12.2
2	28.0	79	224	8.0	18.5	1.5	−4.25	−2.83	6.3c	79	29.5	62.8	100	29.5
3	27.3	79	1,034	37.9	22.0	2.5	−4.20	−3.87	26.2	70	39.6	9.8	50	19.8
4a	17.6	62	773	43.9	20.2	4.2	−4.26	−4.12	34.9	80	39.0	11.1	50	19.5
5	55.0	74	492	8.9	32.4	4.9	−4.20	−3.68	7.1c	80	27.6	13.9	100	27.6
4a	17.6	38b	702	39.9	28.9	3.6	−4.40	−3.94	34.3	86	15.8	9.0	100	15.8
6	66.6	71	548	8.2	23.9	9.2	−4.20	−3.65	7.7c	95	16.0	21.6	100	16.0
7	29.4	38b	571	19.4	18.2	2.1	−4.20	−4.20	17.0	88	14.9	1.7	100	14.9
8	8.3	29b	251	30.2	28.6	2.9	−4.74	−3.76	22.8	75	18.3	17.6	66	12.2
9	17.4	52	612	35.2	22.4	3.7	−3.98	−3.14	36.7	100	69.7	55.7	33	23.2
Median	22.5	62	592	32.7	22.2	3.3	−4.21	−3.72	24.5	83	28.6	15.8	-	17.8
Min.	8.3	29	224	8.0	15.1	0.9	−4.74	−4.20	6.3	70	14.9	1.7	-	12.2
Max.	66.6	79	1,034	59.5	32.4	9.2	−3.98	−2.83	58.7	100	69.7	62.8	-	29.5

^aThe same patient had two products within 2 months from both parents.

^bNormal scale procedures.

^cAn additional CD34 selected graft was administered.