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APOE deficiency aggravated microglial activation. (a) SAH increased the number of microglia in the cortex and white matter (∗P < 0.05, ∗∗P < 0.01, compared to sham, n = 5), while more microglia increased in APOE−/− mice than in WT mice (##P < 0.01). (b) Western blotting showing overexpression of Iba-1 after SAH (∗P < 0.05, ∗∗P < 0.01, compared to sham, n = 5). APOE−/− mice exhibited higher Iba-1 level than WT mice (##P < 0.01). Bar = 50 μM.
