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An S837D substitution mutant is also hyper-resistant to Pdr5 transport substrates. The S837D (JG2176, □, blue line) mutant strain was compared to the S837A mutant (JG2175, ●, orange line) and an isogenic WT control strain (JG2001, ▪▪▪, green line) for relative resistance to (A) cycloheximide and (B) cerulenin.
