Table 1. Hits from the Peroxisome X-pex screen.
| Fly Gene | Allele (s) | Peroxisomal Phenotype | Human Gene(s) | Biological Function in Fly (UniProt) |
|---|---|---|---|---|
| fs(1)h (FBgn0004656) | fs[1]h[A], [B], [C] | Category A & B | BRD2, BRDT, BRD3, BRD4 | Transcriptional regulation |
| Rbcn-3B (FBgn0023510) | Rbcn-3B[A], [B] | Category A | WDR7 | Vacuolar acidification, Notch signaling |
| Coq8 (FBgn0052649) | Coq8[A],[B] | Category A | COQ8B | Protein kinase, electron transport |
| Usp16-45 (FBgn0029763) | Usp16-45[A],[B] | Category A | USP45 | Protein deubiquitination |
| mxc (FBgn0260789) | mxc[A],[B],[C],[D],[E] | Category A | No Human Ortholog | Transcriptional, hemocyte differentiation and proliferation |
| Cp7Fb (FBgn0014465) | Cp7Fb[B] | Category A | No Human Ortholog | Chorion |
| Upf1 (FBgn0030354) | Upf1[A],[B] | Category A | UPF1 | Nonsense mediated decay |
| Upf2 (FBgn0029992) | Upf2[A],[B] | Category A | UPF2 | Nonsense mediated decay |
| Nrg (FBgn0264975) | Nrg[XB] | Category A | NRCAM, NFASC, L1CAM, CHL1 | Cell adhesion |
| Fum1 (FBgn0286222) | Fum1[A] | Category A | FH | TCA cycle enzyme (mitochondria) |
| Coq7 (FBgn0029502) | Coq7[B] | Category A | COQ7 | Ubiquinone biosynthesis (mitochondria) |
| sgg (FBgn0003371) | sgg[A],[B],[E] | Category A | GSK3B, GSK3A | Protein kinase |
| CG17829 (FBgn0025635) | CG17829[A],[B] | Category A | HINFP | Transcriptional regulation |
| CG3149 (FBgn0027564) | CG3149[B] | Category A | RFT1 | Glycolipid translocation |
| Smox (FBgn0025800) | Smox[B] | Category A | SMAD3 | Transcriptional regulation |
| PI4KIIIα (FBgn0267350) | PI4KIIIα [E], [W] | Category A | PI4KA | Synaptic growth, cell polarity, membrane organization |
| MTPAP (FBgn0024360) | MTPAP[A],[B] | Category A | MTPAP | Mitochondrial transcription |
| temp (FBgn0027296) | temp [A], [B] & [D] | Category A | PTAR1 | Rab geranylgeranyltransferase activity |
| TOTAL | 37 hits | 18 fly genes | 23 human genes |
The Fly gene and specific allele are listed along with the phenotype observed in the screen (Category A, B and C). The human homologs of each gene were identified using DIOPT or HCOP (Hu et al. 2011; Braschi et al. 2019). Known biological function of the fly protein is listed according to the annotation in UniProt (Uniprot Consortium 2019).