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. 2019 Nov 25;21(1):e47996. doi: 10.15252/embr.201947996

Figure EV1. Modulation of selected PS1 FAD mutants with different classes of GSMs.

Figure EV1

  • A
    Structure of GSM‐1.
  • B
    Structure of RO‐02.
  • C, D
    ELISA of Aβ species in conditioned media of HEK293/sw cells overexpressing WT or PS1 L166P and R278I mutants treated with GSM‐1 (C), RO‐02 (D), or vehicle (DMSO) showing the secretion of Aβ38, Aβ40, Aβ42, and Aβ43 compared to total Aβ (Aβ38 + Aβ40 + Aβ42 + Aβ43) (n = 2 biological replicates). Data are presented as mean.

Source data are available online for this figure.