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. 2019 Nov 25;21(1):e47996. doi: 10.15252/embr.201947996

Figure 2. Aβ43‐generating PS1 FAD mutants show altered C99 interactions.

Figure 2

  1. Immunoblot analysis of C99–PS1 NTF or full‐length (FL) crosslinks (CL) of the indicated mutants. Samples that were not UV‐irradiated were loaded to control for specificity.
  2. Changes in the ratio of crosslink efficiencies at positions T48 and L49 compared to corresponding controls (n = 4–5 biological replicates).
  3. Changes in the ratio of crosslink efficiencies at positions K54 and V44 compared to corresponding controls (n = 4–5 biological replicates).
Data information: Data in (B) and (C) are presented as mean ± SD.Source data are available online for this figure.