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. 2019 Nov 25;21(1):e47996. doi: 10.15252/embr.201947996

Figure EV3. Aβ42‐lowering effects of RO7019009 on refractory PS1 FAD mutants.

Figure EV3

ELISA of Aβ species in conditioned media of HEK293/sw cells overexpressing WT or mutant PS1 treated with 500 nM RO7019009 or vehicle (DMSO) showing the secretion of Aβ42 compared to total Aβ (Aβ38 + Aβ40 + Aβ42 + Aβ43) (n = 9; including data taken from Fig 4C (n = 5) and 4 additional experiments, data are presented as mean ± SD). Statistical significance was tested using paired t‐test. In case of the V261F and the Y256S mutant, the data were not normally distributed and were therefore assessed using Wilcoxon matched‐pairs signed rank test.Source data are available online for this figure.