Figure 4. Modulation of PS1 FAD mutants with RO7019009.

• A–C
  ELISA of Aβ species in conditioned media of HEK293/sw cells overexpressing WT or mutant PS1 treated with RO7019009 or vehicle (DMSO) showing the secretion of Aβ38 (A), Aβ43 (B), and Aβ42 (C) compared to total Aβ (Aβ38 + Aβ40 + Aβ42 + Aβ43) (n = 5 biological replicates). Note that in some experiments, Aβ38 generation was below the detection limit for some mutants. Data are presented as mean ± SD.

Source data are available online for this figure.