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. 2019 Nov 25;21(1):e47996. doi: 10.15252/embr.201947996

Figure 6. Partial effects of RO7019009 on C99–PS1 crosslink formation.

Figure 6

  1. Immunoblot analysis of C99 V44Bpa crosslinking (CL) to PS1 NTFs (circle) of WT or normally endoproteolysed mutants in the presence of vehicle (DMSO) or RO7019009.
  2. Quantitation of crosslink efficiencies of C99 V44Bpa to the WT or mutant NTF in (A).
  3. Immunoblot analysis of C99 V44Bpa crosslinking to full‐length (FL) PS1 (triangle) of endoproteolysis‐deficient mutants and the corresponding M292D control in the presence of vehicle (DMSO) or RO7019009.
  4. Quantitation of crosslink efficiencies of C99 V44Bpa to the M292 or FAD mutant FL PS1 in (C).
Data information: Data in (B and D) are presented as box plots (line, median; box, 75th–25th percentiles; whiskers, 1.5× interquartile range (IQR); single points represent outliers (> 1.5× IQR away from box)) (n = 7–11 biological replicates).Source data are available online for this figure.