Figure 4.

Mapping of Tel1 Hyperactivating and ATM Disease-Associated Mutations

(A) Tel1 FAT-KIN protomer is shown colored as in Figure 1 with hyperactivating mutations found in Baldo et al. (2008) mapped and shown as green spheres.

(B) Molecular details of a cluster of mutations in kα9 found in cancer and described in hyperactivating Tel1 phenotypes.

(C) Cancer-associated (dark gray spheres) and ataxia-telangiectasia-associated (A-T, purple spheres) mutations at structurally equivalent locations (see Table S1 for details).

(D) Molecular details of G2609 (G2867 in ATM), which is mutated to arginine in A-T. See also Table S1.