Skip to main content
. Author manuscript; available in PMC: 2020 Jan 7.
Published in final edited form as: Cancer Lett. 2018 Sep 15;438:165–173. doi: 10.1016/j.canlet.2018.09.022

Fig. 1.

Fig. 1.

LRP8 is highly expressed in TNBC. a-c Breast cancer samples in the METABRIC data set were stratified by different classification methods. LRP8 was found highly expressed in a TNBC (****p < 0.0001, Student’s t-Test), b basal-like subtype of the molecular subtypes (Normal: normal-like breast cancer, Lum A: luminal A subtype, Lum B: luminal B subtype, CL: claudin-low subtype, Basal: basal-like subtype; ****p < 0.0001, One-way ANOVA), and c IC10 of the integrative clusters (****p < 0.0001, One-way ANOVA). d-f Percentage of LRP8 copy number gain or amplification in breast cancer subtypes using different classifications (****p < 0.0001, χ2-test). g Comparison of LRP8 expression between breast cancer patients with LRP8 diploid (neutral) and those with LRP8 copy number gain or amplification (Amp) (****p < 0.0001, Student’s t-Test). h, i Kaplan-Meier survival analysis of breast cancer patients with low or high expression of LRP8. h data from the METABRIC data set and i data from Kaplan-Meier Plotter [32].