Table 1.
Proportion of patients with high HSP90 isoform expression according to clinicopathological characteristics of patients with colorectal cancer
| Variables | No. of cases | HSP90α | HSP90β | GRP94 | TRAP1 | ||||
|---|---|---|---|---|---|---|---|---|---|
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| No. (%) | P | No. (%) | P | No. (%) | P | No. (%) | P | ||
| Total | 129 | 99 (77) | 68 (53) | 90 (70) | 83 (64) | ||||
| Age (years) | |||||||||
| < 70 | 71 | 56 (79) | 0.538 | 37 (52) | 1.000 | 46 (65) | 0.184 | 47 (66) | 0.713 |
| ≥ 70 | 58 | 43 (74) | 31 (53) | 44 (76) | 36 (62) | ||||
| Sex | |||||||||
| Male | 76 | 61 (80) | 0.293 | 36 (47) | 0.156 | 52 (68) | 0.846 | 51 (67) | 0.460 |
| Female | 53 | 38 (72) | 32 (60) | 38 (72) | 32 (60) | ||||
| Location | |||||||||
| Right | 30 | 25 (83) | 0.393 | 15 (50) | 0.814 | 20 (67) | 0.952 | 19 (63) | 0.128 |
| Transverse | 11 | 7 (64) | 5 (46) | 8 (73) | 4 (36) | ||||
| Left | 88 | 67 (76) | 48 (55) | 62 (71) | 60 (68) | ||||
| Differentiation | |||||||||
| Well | 30 | 23 (77) | 1.000 | 14 (47) | 0.389 | 26 (87) | 0.029 | 22 (74) | 0.105 |
| Moderately | 91 | 70 (77) | 49 (54) | 59 (65) | 58 (63) | ||||
| Poorly | 8 | 6 (75) | 5 (63) | 5 (63) | 3 (38) | ||||
| Size (cm) | |||||||||
| < 4 | 66 | 47 (71) | 0.148 | 27 (41) | 0.008 | 46 (70) | 1.000 | 40 (61) | 0.462 |
| ≥ 4 | 63 | 52 (83) | 41 (66) | 44 (70) | 43 (68) | ||||
| Pathological T stage | |||||||||
| pT1 | 2 | 2 (100) | 0.011 | 1 (50) | 0.712 | 1 (50) | 0.254 | 1 (50) | 0.138 |
| pT2 | 17 | 8 (47) | 9 (53) | 13 (77) | 12 (71) | ||||
| pT3 | 85 | 67 (79) | 46 (54) | 60 (71) | 58 (68) | ||||
| pT4 | 25 | 22 (88) | 12 (48) | 16 (64) | 12 (48) | ||||
| Pathological N stage | |||||||||
| pN0 | 65 | 46 (71) | 0.288 | 33 (51) | 0.871 | 46 (71) | 0.914 | 41 (63) | 0.753 |
| pN1 | 43 | 38 (88) | 25 (58) | 29 (67) | 28 (65) | ||||
| pN2 | 21 | 15 (71) | 10 (48) | 15 (71) | 14 (67) | ||||
| Distant metastasis | |||||||||
| No metastasis | 109 | 82 (75) | 0.405 | 58 (53) | 0.812 | 76 (70) | 1.000 | 71 (65) | 0.800 |
| Metastasis | 20 | 17 (85) | 10 (10) | 14 (70) | 12 (60) | ||||
| TNM stage | |||||||||
| I | 15 | 8 (53) | 0.073 | 7 (47) | 0.856 | 11 (73) | 0.721 | 10 (67) | 0.861 |
| II | 45 | 35 (78) | 24 (53) | 32 (71) | 27 (60) | ||||
| III | 49 | 39 (80) | 27 (55) | 33 (67) | 34 (69) | ||||
| IV | 20 | 17 (85) | 10 (50) | 14 (70) | 12 (60) | ||||
| Lymphovascular invasion | |||||||||
| Negative | 100 | 77 (77) | 1.000 | 55 (55) | 0.400 | 72 (72) | 0.360 | 62 (62) | 0.381 |
| Positive | 29 | 22 (76) | 13 (45) | 18 (62) | 21 (72) | ||||
| HSP90α | |||||||||
| Low | 30 | 12 (40) | 0.144 | 27 (90) | 0.006 | 23 (77) | 0.130 | ||
| High | 99 | 56 (57) | 63 (64) | 60 (61) | |||||
| HSP90β | |||||||||
| Low | 61 | 43 (71) | 0.144 | 41 (46) | 0.570 | 34 (56) | 0.066 | ||
| High | 68 | 56 (82) | 49 (54) | 49 (72) | |||||
| GRP94 | |||||||||
| Low | 39 | 36 (92) | 0.006 | 19 (49) | 0.570 | 19 (49) | 0.017 | ||
| High | 90 | 63 (70) | 49 (54) | 64 (71) | |||||
| TRAP1 | |||||||||
| Low | 46 | 39 (85) | 0.130 | 19 (41) | 0.066 | 26 (30) | 0.017 | ||
| High | 83 | 60 (72) | 49 (59) | 64 (71) | |||||