Table 3.
Univariate and multivariate Cox regression analyses of disease-free survival in breast cancer patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
|
| ||||
| HR (95% CI) | P value | HR (95%CI) | P value | |
| Age (years), ≤ 50 versus > 50 | 0.807 (0.200-3.259) | 0.764 | ||
| Menopausal status, Premenopausal versus Postmenopausal | 2.007 (0.531-7.582) | 0.304 | ||
| Tumor size (cm), ≤ 2 versus > 2 | 3.102 (1.313-7.330) | 0.010 | 1.919 (0.576-6.393) | 0.288 |
| Lymph node status, negative versus positive | 3.804 (1.565-9.243) | 0.003 | 0.813 (0.196-3.367) | 0.775 |
| Grade I-II versus III | 1.120 (0.312-4.022) | 0.862 | ||
| ER status, negative versus positive | 0.524 (0.223-1.228) | 0.137 | ||
| PR status, negative versus positive | 0.422 (0.175-1.018) | 0.055 | ||
| HER-2/neu status, negative versus positive | 5.602 (2.191-14.326) | 0.000 | 3.117 (0.894-10.874) | 0.075 |
| TNM stage, I-II versus III | 3.787 (2.109-6.802) | 0.000 | 2.481 (1.194-5.159) | 0.015 |
| SPRY4-IT1 expression, low versus high | 10.500 (3.591-30.698) | 0.000 | 4.322 (1.205-15.500) | 0.025 |