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Different expression levels of SREBP1 may affect the sensitivity of colon cancer cells to 5-FU. A. SREBP1 overexpression HT29 cells are less sensitive to 5-FU than a control group by CCK-8 detection. B. SREBP1 knocked down SW620 cells by transfected with SREBP1 shRNA are more sensitive to 5-FU than a control group by CCK-8 detection. C, D. IC50 of SREBP1 over-expression HT29 cells and SREBP1 knocked down SW620 cells compared with the control group.
