Figure 4.

APC deficiency results in the downregulation of intestinal PPARα target genes. A. LPL and PPARα proteins were measured by western blot with specific antibodies in the intestine of the Apc^Min/+ and WT mice (WT: wild type mouse, Min: Apc^Min/+ mouse, n=3). B-D. Aox, Acot1, Acot2, Acaa2, Gstk1, Gstm3, Gsst, Npc1l1, CD36, Mttp, Abca1, Abcg5 and Abcg8 were measured by qRT-PCR in the intestine of Apc^Min/+ and the WT mice (n=3). Data are expressed as the Mean ± SEM. The differences between the mean values were assessed by Student’s t-tests and analyzed using GraphPad Prism software 7.0. *P<0.05, **P<0.01 and ***P<0.001 and ns, not significant.