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. 2019 Oct 31;49:258–268. doi: 10.1016/j.ebiom.2019.10.011

Fig 4.

Fig 4

Detailed phenotypic and functional characterization of HLA-DR+CD8+T cells in cirrhotic patients. (a) Expression of maturation surface markers (left panel; n = 60) and baseline intracellular functional markers (right panel) in HLA-DR−CD8+T cells compared to HLA-DR+CD8+T cells. (b) Expression of activation and inhibition surface markers, including expression of T-regulator cells markers (CD25 and FOXP-3). (c) Elevated frequency of CD8+T cells co-expressing PD1 and HLA-DR in patients with poor outcomes. (d) In vitro cytokines production of HLA-DR−CD8+ and HLA-DR+CD8+T cells isolated from cirrhotic patients following 48 h CD3/CD28 beads stimulation (n = 10). (e) Co-expression of natural killer T (NKT) (left panel) and mucosal-associated invariant T (MAIT) cell markers (right panel) on HLA-DR+CD8+T cells from HV (n = 4 and n = 9, respectively) and cirrhotic patients (n = 10 and n = 18 respectively). * p<0.05; ** p<0.0001 (Wilcoxon signed-rank test (a; b; d; e) and Mann-Whitney U test (c)).