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. 2019 Oct 31;49:258–268. doi: 10.1016/j.ebiom.2019.10.011

Fig 5.

Fig 5

Transcriptional features of HLA-DR+CD8+T cells from cirrhotic patients. Following live/ dead exclusion, flow cytometry sorted cells were assessed for the expression of 579 genes involved in immune responses using Nanostring™ technology. Gene expression is reported in HLA-DR+CD8+T cells from cirrhotic patients as fold change of detected mRNA expression levels normalised to baseline values observed in HLA-DR−CD8+ paired samples (n = 3, CLD patients; n = 2, AD patients; n = 1)): (a) Heat-map created using Java TreeView 1.1.6r4 representing statistically significant transcriptional changes between HLA-DR+ and HLA-DR− CD8+T cells in cirrhotic patients (n = 3). (b) Relevant transcriptional changes between HLA-DR+ and HLA-DR− CD8+T cells in cirrhotic patients. (c) Ex-vivo apoptosis staining performed to explore levels of apoptosis in HLA-DR+ and HLA-DR−CD8+T cells from cirrhotic patients (n = 8). * p<0.05; •p<0.1 (Wilcoxon signed-rank test).