Table 1.
Components of biological variation in healthy subjects.
| B2M | EIF2C1 | RNaseP | TERT | |
|---|---|---|---|---|
| Number of samplesa | 114 | 177 | 121 | 177 |
| Median (copies/ml) | 1434⋅11 | 1399⋅62 | 1056⋅03 | 1532⋅84 |
| Range (copies/ml) | 42⋅57–2509⋅30 | 30⋅60–3340⋅73 | 22⋅34–2194⋅19 | 34⋅23–3481⋅28 |
| CVI (%) | 23⋅6 | 23⋅9 | 25⋅4 | 23⋅3 |
| CVG (%) | 25⋅5 | 29⋅6 | 27⋅1 | 30⋅0 |
| CVA (%) | 6⋅6 | 6⋅4 | 8⋅4 | 6⋅6 |
| IIb | 0⋅96 | 0⋅84 | 0⋅99 | 0⋅81 |
| RCVc (%) | 67⋅9 | 68⋅5 | 74⋅1 | 67⋅1 |
| nd | 4 | 4 | 5 | 4 |
a
Number of samples analysed after exclusion of outliers;.
b
II, Index of individuality;.
c
RCV, reference change value at 95% significance;.
d
n, number of samples required to estimate homeostatic set point. Abbreviations: CVI, within-subject coefficient of variation; CVG, between-subject coefficient of variation; CVA, analytical coefficient of variation.