Fig. 1.

G12 decreased HBsAg in HBV carrier mouse model. HDI-HBV-carrier mice were injected with 0.5 mg m336 antibody, G12 or 40 IU HBIG (a). Mice were bled and kinetics of HBsAg (b) and HBeAg (c) levels in the control m336 antibody (black), HBIG (red), or G12 (blue) groups are shown. The data represent mean ± SEM, n = 9 before day 4 and n = 7 after day 4 because two mice were sacrificed at day 3. (d) The HBV DNA level was quantified before or 20 days after the treatment. Significant differences between groups are indicated on the top (* p < 0.05; two-tailed unpaired Mann-Whitney U test). (e) The G12 levels in individual mice at 24, 29 and 34 days after one single injection are shown. (f) The HBsAg levels at 24, 29 and 34 days after the G12 infusion in each mouse are also presented.