Figure 3.

This is an overview of the main components of the HSC niche and their alterations in leukemia. Simplified schematic of the normal HSC niche (left) and leukemic niche (right). The diagram illustrates some of the best characterized candidate niche cells and factors that have been found altered in leukemias. The right panel summarizes niche abnormalities observed in various experimental models representing different leukemia types. (Figure retrieved from the article of Sánchez-Aguilera and Méndez-Ferrer[65] after permission for use). HSC – Hematopoietic stem cell; LSC – Leukemia stem cell