Table 2.

Generalized estimation equation results modeling significant changes over time (mean duration of 2 years) in connectivity. MFG connectivity significantly increased by 0.264 units per year, which was lower by 0.1 units per unit PiB SUVR. *p < 0.05; **p < 0.01; ***p < 0.001

Predicting changes in MFG connectivity with memory encoding network
	β (unstandardized)	Standard error
Intercept	− 1.532	1.976
Covariates of no interest
Sex (M:F)	− 0.012	0.123
Education (years)	0.015	0.018
Race (B:W)	0.032	0.253
Age (years)	0.015	0.010
Intracranial volume (cubic mm)	0.000	0.000
Predictors
Time (years)	0.264*	0.065
amyloid (PiB SUVR)	− 0.049	0.237
glucose metabolism (FDG SUVR)	− 0.034	0.516
Normalized hippocampal volume	− 13.853	61.567
Normalized WMH volume	0.063	0.092
Interactions
Time × PiB	− 0.100*	0.031
Time × FDG	Not significant, not included
Time × hippocampal volume	Not significant, not included
Time × WMH volume	Not significant, not included