Table 4.
Mean salicylic acid pharmacokinetic parameters after oral doses of 2-hydroxybenzylamine
| Parameter | 2-Hydroxybenzylamine acetate dose | |||
|---|---|---|---|---|
| 500 mg (n = 6) | 750 mg (n = 5–6) | |||
| Day 1 (first dose) | Day 15 (last dose) | Day 1 (first dose) | Day 15 (last dose) | |
| Tmax (h) | 5.00 ± 1.10 | 3.50 ± 1.22 | 4.67 ± 1.03 | 3.20 ± 1.79 |
| Cmax (ng/mL) | 7635 ± 2112 | 11,382 ± 4118 | 12,092 ± 2619 | 12,768 ± 3703 |
| AUC0–8h (h·ng/mL) | 42,458 ± 12,070 | 75,288 ± 28,095 | 65,935 ± 13,775 | 81,826 ± 28,120 |
| AUC (h·ng/mL) | 123,075 ± 55,044 | 117,842 ± 41,615 | ||
Cmax, maximum observed plasma concentration; Tmax, time to reach Cmax; AUC, area under the concentration-time curve from zero to infinity; AUC0–8, area under the dosing interval curve.