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Synthesis of quinazolindione compounds 2 to 8. (i) Acetylacetone, AcOH, EtOH, and reflux; (ii) benzenesulphonyl chloride, pyridine, and reflux; (iii) toluenesulphonyl chloride, pyridine, and reflux; (iv) ethyl cyanoacetate, EtOH, and reflux; (v) benzyl chloride, EtOH, and reflux; (vi) acetyl chloride, EtOH, and reflux; and (vii) chloroacetyl chloride, EtOH, and reflux.
