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. 2020 Jan 6;20:7. doi: 10.1186/s12886-019-1292-x

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Neovascularization was inhibited after BMSC or Conbercept injection. a Schematic process of establishing an OIR animal model by exposure to 75% oxygen from postnatal day 7 (P7) to P12 and return to room air with or without intravitreal injection. b P17 retinal flat-mount revealed neovascular tufts (NVT, arrowheads) and avascular areas developed after high oxygen exposure (OIR-blank and OIR-DMEN) but shrinked following BMSC (OIR-BMSC) or Conbercept (OIR-CON) injection. c Avascular areas were presented as percentages to the whole retina; both BMSC and Conbercept injection significantly reduced avascular areas. d Similar quantification was calculated in regard to the neovascular tufts (NVT) areas. *, P < 0.05 versus OIR-blank; n = 9