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. 2020 Jan 6;20:12. doi: 10.1186/s12885-019-6425-3

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Loss of ARID1a in microsatellite-instable (MSI-H) EAC. (a + b) Barrett’s adenocarcinoma (white arrow highlights Barrett’s mucosa with high grade dysplasia, blue arrow highlights highly inflamed and poorly cohesive Barrett’s carcinoma; HE, 2,5x; HE, × 5;) with (c) loss of ARID1a in Barrett’s carcinoma and strong nuclear positivity in high grade dysplasia (IHC, × 5) and (d) loss of the mismatch-repair-protein MLH1 in Barrett’s adenocarcinoma (IHC, × 5)