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. 2020 Jan 6;17:8. doi: 10.1186/s12974-019-1683-1

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Axon terminal C1q labeling is observed in association with synaptic vesicles. a, b Presynaptic C1q is visualized in association with vesicles within glutamatergic-like axon boutons and rarely on the plasma membrane. a C1q is localized in axon terminals in association with spherical vesicles. The perforated asymmetric synapse can be seen clearly, along with a distinct spine apparatus in the postsynaptic compartment. b C1q labeling is observed in both pre- and postsynaptic compartments of the same synaptic profile. The dendritic spine head of this profile can be seen emanating from a dendritic shaft containing mitochondria. Synapses are between arrows. Color-coded arrowheads (purple) point to C1q immunoreactivity. Profiles are pseudocolored for clarity. Ax, axon; Sp, spine; Mit, mitochondria. Scale bars, 200 nm