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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biomaterials. 2019 Aug 20;222:119441. doi: 10.1016/j.biomaterials.2019.119441

Fig. 4. Cell-based antiretroviral activities.

Fig. 4.

Antiretroviral activity was determined in MDM treated for 8 h with 100 μM FTC or NM2FTC and then infected with HIV-1ADA at 1 to 30 days following drug loading. HIV-1 replication was determined 10 days after infection by A) Time course HIV-1 RT activity in culture supernatants. RT activity results were confirmed by B) HIV-1p24 antigen expression (brown stain) of adherent MDM. NM2FTC protected MDM from HIV-1 infection at all time points. Results were normalized to positive control cells. All results are shown as the mean ± SEM with n = 3. C) Comparative HIV-1 RT activity at day 30 showing statistical significance in the % RT activity between FTC and NM2FTC treatments using unpaired two tailed t-test at ****P < 0.0001.