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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biomaterials. 2019 Aug 20;222:119441. doi: 10.1016/j.biomaterials.2019.119441

Fig. 5. PK and biodistribution of FTC and NM2FTC in rats.

Fig. 5.

Blood and tissue M2FTC and FTC concentrations were determined over 28 days. A) FTC and M2FTC levels in whole blood after a single IM injection of FTC or NM2FTC in Sprague Dawley rats (45 mg/kg FTC equivalents). M2FTC and FTC concentrations were determined in (B) lymph nodes, (C) spleen, and (D) liver. Data are expressed as mean ± SEM for n = 5 rats per group. Formation of FTC-TP in (E) lymph node and (F) spleen cells were determined. Drug concentrations were quantified by UPLC-MS/MS.