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Cortical loss after experimental CHI. There is a clear decrease in cortical volume as measured on T2-weighted images 50 days postinjury compared with baseline (A), with a greater percentage volume change after double injury (n = 12) compared with sham surgery (n = 9) and single injury (n = 12). Reduction of cortical volume is associated with the number of impacts. Data are means. ‡ indicates P < .05 versus the sham; #, P < .05 versus the single CHI; SMCx, sensorimotor cortex.
