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. 2019 Apr;40(4):601–608. doi: 10.3174/ajnr.A6014

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© 2019 by American Journal of Neuroradiology

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Fig 4. — Behavioral deficits after CHI. mNSS (A) and beam-walking duration (B) after single and double CHI compared with sham surgery. In single-injury rodents, the mNSS score and beam-walking duration follow a similar time course compared with animals in the sham group; whereas in double-injury rodents, the mNSS score and beam-walking duration both increase significantly after CHI by day 7 and do not resolve by day 50. Locomotive activity as measured by movement duration (C) and travel distance (D) in the open-field trial after single and double CHI is impaired and persisted at day 50 after double injury. Data are means. ‡ indicates P < .05 versus the sham; asterisk, P < .05 versus baseline (day 0 [D0]); #, P < .05 versus the single CHI.