Table 1.

The expression of the NER proteins in different histological subtypes of primary GCTs (n = 207)

		ERCC1				XPF				XPA
Histological subtype	N	Mean HS	SEM	Median	p valuea	Mean HS	SEM	Median	p value	Mean HS	SEM	Median	p value
Normal testis	49	0.0	0.0	0	NA	29.4	7.0	0	NA	0.0	0.0	0	NA
Germ cell tumoursb	207	13.5	2.9	0.0	<  0.01	213.4	6.2	220.0	<  0.01	51.6	4.5	20.0	<  0.01
Seminoma	64	2.2	1.6	0	<  0.01	182.1	12.4	200	<  0.01	41.4	7.3	10	<  0.01
Embryonal carcinoma	118	2.2	0.9	0	<  0.01	224.0	6.9	220	<  0.01	19.9	3.4	0	<  0.01
Yolk sac tumour	30	14.0	6.7	0	<  0.01	202.4	20.4	210	<  0.01	87.4	15.0	50	<  0.01
Choriocarcinoma	15	15.3	7.1	0	<  0.01	181.7	24.1	200	<  0.01	53.8	16.2	50	<  0.01
Teratoma	41	56.0	11.6	20	<  0.01	186.9	13.2	180	<  0.01	103.4	10.6	90	<  0.01
GCNIS	71	4.3	4.2	0	<  0.01	193.1	13.0	200	<  0.01	7.6	3.3	0	<  0.01

Boldface p value denotes statistical significance < 0.05

NA Not applicable; GCNIS Germ cell neoplasia in situ; SEM Standard error of the mean; HS Histoscore

^aCompared to normal testicular tissue

^bThe highest NER expression in any histologic subtype in case of mixed GCTs