Table 2.
Patient’s characteristics according to the expression of individual NER proteins in primary tumour (n = 207)
| ERCC1 | XPF | XPA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | N | Mean HS | SEM | Median | p value | Mean HS | SEM | Median | p value | Mean HS | SEM | Median | p value |
| All patients | 207 | 13.5 | 2.9 | 0.0 | NA | 213.4 | 6.2 | 220.0 | NA | 51.6 | 4.5 | 20.0 | NA |
| Histology | |||||||||||||
| Seminoma | 38 | 1.9 | 6.8 | 0.0 | 0.0807 | 163.0 | 13.8 | 200.0 | ***0.0015 | 31.9 | 10.5 | 5.0 | *0.0196 |
| Non-seminomaNNNN Non-seminona | 169 | 15.9 | 3.2 | 0.0 | 224.6 | 6.6 | 240.0 | 56.0 | 5.0 | 30.0 | |||
| Tumour primary | |||||||||||||
| Primary TGCTs | 200 | 13.5 | 2.9 | 0.0 | 0.4771 | 212.2 | 6.2 | 210.0 | 0.2250 | 50.8 | 4.6 | 20.0 | 0.0676 |
| Extragonadal GCTs | 7 | 12.9 | 15.6 | 0.0 | 248.3 | 35.6 | 300.0 | 79.2 | 26.3 | 80.0 | |||
| IGCCCG risk group | |||||||||||||
| Good prognosis | 158 | 9.9 | 3.3 | 0.0 | *0.0322 | 210.5 | 7.0 | 215.0 | 0.3983 | 44.7 | 5.0 | 10.0 | ***0.0002 |
| Intermediate | 23 | 21.3 | 8.5 | 0.0 | 239.8 | 18.2 | 265.0 | 60.2 | 13.1 | 50.0 | |||
| Poor prognosis | 26 | 28.2 | 8.2 | 0.0 | 206.0 | 17.4 | 200.0 | 91.8 | 13.4 | 75.0 | |||
| Number of metastatic sites | |||||||||||||
| 0 | 54 | 13.4 | 5.6 | 0.0 | 0.5566 | 216.3 | 11.9 | 210.0 | 0.8651 | 49.3 | 8.7 | 20.0 | 0.0628 |
| 1 to 2 | 124 | 11.9 | 3.7 | 0.0 | 210.3 | 8.0 | 210.0 | 47.0 | 5.7 | 20.0 | |||
| > 3 | 29 | 20.6 | 7.9 | 0.0 | 220.2 | 16.6 | 250.0 | 82.5 | 13.0 | 55.0 | |||
| Retroperitoneal lymph nodes metastases | |||||||||||||
| Absent | 61 | 13.4 | 5.3 | 0,0 | 0.5226 | 215.4 | 11.2 | 210.0 | 0.8157 | 53.9 | 8.3 | 20.0 | 0.7993 |
| Present | 146 | 13.5 | 3.4 | 0.0 | 212.4 | 7.4 | 220.0 | 50.6 | 5.4 | 20.0 | |||
| Mediastinal lymph nodes metastases | |||||||||||||
| Absent | 189 | 12.8 | 3.0 | 0.0 | 0.9408 | 213.3 | 6.5 | 215.0 | 0.9501 | 50.2 | 4.7 | 20.0 | 0.4597 |
| Present | 18 | 21.2 | 10.0 | 0.0 | 213.1 | 20.6 | 225.0 | 72.7 | 16.6 | 75.0 | |||
| Lung metastases | |||||||||||||
| Absent | 160 | 10.9 | 3.3 | 0.0 | 0.1664 | 208.6 | 7.0 | 205.0 | 0.1478 | 47.6 | 5.1 | 10.0 | *0.0252 |
| Present | 47 | 22.3 | 6.0 | 0.0 | 229.2 | 12.8 | 257.5 | 67.0 | 9.7 | 50.0 | |||
| Liver | |||||||||||||
| Absent | 197 | 12.7 | 2.9 | 0.0 | 0.0510 | 213.0 | 6.3 | 210.0 | 0.8140 | 49.1 | 4.6 | 20.0 | ***0.0037 |
| Present | 10 | 28.0 | 13.0 | 0.0 | 219.0 | 27.7 | 250.0 | 110.6 | 21.1 | 120.0 | |||
| Non-pulmonary visceral metastases | |||||||||||||
| Absent | 194 | 13.2 | 3.0 | 0.0 | 0.2293 | 213.1 | 6.4 | 210.0 | 0.9441 | 49.0 | 4.6 | 20.0 | ***0.0032 |
| Present | 13 | 16.5 | 11.4 | 0.0 | 216.2 | 24.3 | 230.0 | 101.4 | 19.1 | 70.0 | |||
| S stage | |||||||||||||
| 0 | 78 | 9.3 | 4.6 | 0.0 | *0.0455 | 198.9 | 9.7 | 200.0 | 0.3526 | 38.5 | 7.1 | 5.0 | ***0.0004 |
| 1 | 78 | 6.9 | 4.6 | 0.0 | 218.9 | 9.8 | 240.0 | 51.6 | 7.1 | 20.0 | |||
| 2 | 29 | 29.7 | 7.5 | 0.0 | 232.9 | 16.0 | 250.0 | 61.9 | 12.1 | 50.0 | |||
| 3 | 16 | 36.6 | 10.1 | 0.0 | 226.0 | 22.2 | 240.0 | 102.3 | 16.2 | 100.0 | |||
| unknown | 6 | ||||||||||||
Boldface p value denotes statistical significance < 0.05: *p < 0.05; **p < 0.01, ***p < 0.005
NA Not applicable; TGCT Testicular germ cell tumour; GCT Germ cell tumour; IGCCCG International Germ Cell Consensus Classification Group; HS Histoscore; SEM Standard error of the mean