Table 1.
Demographics and fluctuation scores of the cohorts
| A | HC (n = 22) | DLB (n = 92) | AD (n = 70) | Between-group differences |
| Gender (m/f) | 11/11 | 39/40 | 26/32 | χ2 = 0.42, p = 0.81 |
| Age | 66.5 ± 7.8 | 70.1 ± 9.4 | 74.4 ± 8.3 |
AD vs HC: p = 0.0010 AD vs DLB: p = 0.0084 DLB vs HC: NS |
| MMSE | 28.9 ± 0.9 | 25.6 ± 4.0 | 23.8 ± 3.8 |
DLB vs HC: p = 0.0001 AD vs HC: p < 0.0001 DLB vs AD: NS |
| MCFS | 0.3 ± 0.6 | 1.9 ± 1.2 | 0.7 ± 1.0 |
DLB vs HC: p < 0.0001 DLB vs AD: p < 0.0001 AD vs HC: NS |
| B | HC (n = 22) | DLB (n = 79) | AD (n = 58) | Between-group differences |
| Gender (m/f) | 11/11 | 39/40 | 26/32 | χ2 = 0.33, p = 0.85 |
| Age | 66.5 ± 7.8 | 70.3 ± 9.5 | 73.7 ± 8.3 |
AD vs HC: p = 0.0045 DLB vs HC: NS DLB vs AD: NS |
| MMSE | 28.9 ± 0.9 | 25.8 ± 3.8 | 24.4 ± 3.2 |
DLB vs HC: p = 0.0002 AD vs HC: p < 0.0001 DLB vs AD: NS |
| MCFS | 0.3 ± 0.6 | 1.8 ± 1.2 | 0.6 ± 0.9 |
DLB vs HC: p < 0.0001 DLB vs AD: p < 0.0001 AD vs HC: NS |
(A) Cohort of the voxel-based morphometry analysis. (B) Cohort of the functional connectivity analysis. Data are presented as mean ± SD except where noted. Abbreviations: AD Alzheimer’s disease, DLB dementia with Lewy bodies, HC healthy controls, f female, m male, MCFS Mayo Clinic Fluctuation Scale, MMSE Mini-Mental State Examination, NS non-significant