Table 2.
Distribution frequencies of Angpt2 genotypes in controls and patients with colorectal cancer
| Variable | Controls N=1043 (%) | Patients N=379 (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs2442598 | ||||
| AA | 275 (26.4) | 100 (26.4) | 1.00 (reference) | 1.00 (reference) |
| AT | 544 (52.2) | 183 (48.5) | 0.925 (0.697─1.228) | 0.935 (0.667─1.309) |
| TT | 224 (21.5) | 96 (25.3) | 1.179 (0.846─1.641) | 1.224 (0.825─1.815) |
| AT+TT | 648 (72.0) | 507 (73.0) | 0.999 (0.765─1.304) | 1.021 (0.745─1.399) |
| rs734701 | ||||
| TT | 353 (33.8) | 113 (29.8) | 1.00 (reference) | 1.00 (reference) |
| TC | 476 (45.6) | 195 (51.5) | 1.280 (0.977─1.676) | 1.297 (0.948─1.773) |
| CC | 214 (20.5) | 71 (18.7) | 1.036 (0.736─1.459) | 1.099 (0.730─1.654) |
| TC+CC | 595 (66.1) | 469 (67.5) | 1.204 (0.933─1.554) | 1.228 (0.911─1.656) |
| rs1823375 | ||||
| CC | 516 (49.5) | 172 (45.4) | 1.00 (reference) | 1.00 (reference) |
| CG | 442 (42.4) | 173 (45.6) | 1.174 (0.918─1.502) | 1.340 (1.002─1.794)* |
| GG | 85 (8.1) | 34 (9.0) | 1.200 (0.778─1.851) | 1.082 (0.646─1.810) |
| CG+GG | 449 (49.9) | 353 (50.8) | 1.178 (0.931─1.492) | 1.293 (0.979─1.708) |
| rs11137037 | ||||
| AA | 491 (47.1) | 188 (49.6) | 1.00 (reference) | 1.00 (reference) |
| AC | 392 (37.6) | 123 (32.5) | 0.819 (0.630─1.066) | 0.953 (0.701─1.296) |
| CC | 160 (15.3) | 68 (17.9) | 1.110 (0.798─1.544) | 1.200 (0.806─1.786) |
| AC+CC | 483 (53.7) | 351 (50.5) | 0.904 (0.714─1.143) | 1.030 (0.780─1.359) |
| rs12674822 | ||||
| GG | 314 (30.1) | 89 (27.5) | 1.00 (reference) | 1.00 (reference) |
| GT | 485 (46.5) | 352 (50.6) | 1.419 (1.063─1.892)* | 1.443 (1.025─2.031)* |
| TT | 244 (23.4) | 152 (21.9) | 1.374 (0.984─1.918) | 1.306 (0.882─1.934) |
| GT+TT | 617 (68.6) | 504 (72.5) | 1.403 (1.069─1.842)* | 1.384 (1.006─1.904)* |
The odds ratios (ORs) and their associated 95% confidence intervals (CIs) were estimated by logistic regression analysis. The adjusted odds ratios (AORs) with their associated 95% CIs were estimated by multiple logistic regression analysis that controlled for smoking, alcohol consumption and age. * p < 0.05 was considered to be statistically significant.